We haven’t published any news for a long time. From one hand, it’s wonderful that we are such a busy persons. From the other hand – it seems that nothing interesting had happened. But that is not true. That’s why we are going to tell about our recent trip to Pushino-upon-Oka – the town of peaceful biology.
We were invited by Constantin Lapin, a sensational vet surgeon, but why he is so sensational we’ll tell you later. Some theory first.
Now, imagine that we should trace the influence of some medicine on the organism functions during some periods of time, for example, within an hour, after six hours, after twelve hours, two days later, after a month etc. And to learn the medical impact we need blood tests. Scenario №1 – we have dozen of rats, and we cut one after an hour, cut the other after the six hours, than we take the third one… It is not interesting to continue. But that wasn’t the “Doctor Moreau Chronicles”, that was the ordinary way real practice goes on.
Alternative scenario. We have one rat and take the corresponding number of blood samples from it. Does everybody like blood tests? Fine, you don’t care about animal feelings, but imagine how the creature is stressed, being punctured, and how does it result in biochemical composition of its blood.
Nevertheless, if you install the catheter directly into the jugular vein, then you can tike blood samples any time you want, and the creature will not recognize it. So – up with catheterization! But who is skilled enough for such a target? And what tiny catheter should be used?
...We go on and on endless subterranean tonnels. They divide, some of them turn instantly and disappear while we pass them. We meet people. Sometimes the signposts. But we still go on and on under the ground. Rather associative.
At last, we go up and enter the tidy surgery room. Today two tiny beasts will have surgery. Don’t worry, there will be a happy end.
One – Constantin stretch out to the surface a thin pulsating vein. Two – he enters the vein with the catheter through the microscopic puncture. Three – the proximal end of the catheter (the one with the connector) is fixed above the animal back. The rat is taken to a special cage, where it will wake up. Some time later it will give some blood for the sample, but will not notice it.
And here is the second rat. Comparing to the previous one, it doesn’t feeling well under anesthesia. One – one more time the vein is stretched out to the surface, but this time it is flat and bloodless. “Ah, I dislike this vein, says Constantin, I dislike it completely. How should I puncture it?” One wrong movement, and a tiny ribbon of flesh, much thinner than one millimeter, will be torn apart and the animal will die. “Ah, I simply hate this vein”, says Constantin, and inserts the catheter directly into it. Three (did we miss the “Two”?) – and a catheter of different construction is fixed above the animal back. Some sewage – and one more rat on the clean sawdust is waiting for the consciousness to regain.
And that is a wonderful new trend. Constantin Lapin wasn’t only the inspirator of microcatheters manufacture – and a special team of professionals, including one of the pioneers of New Age vet medical disposables in Russia, Catherine Zhukova, was involved into the design and development - but also a bright promoter of the method itself, teaching specialists to use the catheterization in their common practice countrywide.
And Mystra…))) as usual is looking forward with some interest and has strong intention to support the expansion of this method in Russia, and also to help some old, antihuman practices to disappear, the faster - the better. Because we like animals.
From left to right: Nikolay Zinenko, Constantin Lapin and Catherine Zhukova in front of the Institute of Theoretical and Experimental Biophysics of Russian Academy of Sciences
During the whole year we were arranging the trading company everyday work. At the previous Zdravo-Expo we’ve collected some samples and catalogues, and also have learned some company names.
It’s one thing when you have several guys you familiar with in one exhibition hall. The different thing is when there are several unfamiliar fellows, and everybody knows each other. No one knew us by sight, besides a couple or three our major business partners, but only a bunch of men never heard about Rihards from Mystra. Since this famous person is very precise in schedule fulfilment (never running from one booth to another with a smiling muzzle like Irish Setters usually do), it’s easy to forgive cordial exhibitors for their attempts to combine my Teutonic height with a Roman-German name. Anyway, it seems that the time of misconceptions is passing by – all the telephone calls participants now materialized.
It’s really nice to find yourself among person you got to know. But I couldn’t say, that the exhibition was not informative, not at all. Lots of news, but all this news were of a new sort – not the new horizons, but the clarification of the details in the familiar field. And also a really pleasant surprises – I’m really glad that I could get acquainted with Nur Shakirov, head of the Kazan medical instruments plant, the man of the two epochs, who’s got plenty of things to learn from.
I wonder how would be the next Zdravo-Expo for us. Is it a time for booth booking?
Nikolay Zinenko, 20th of December, 2016
In the "Expocentre" (Moscow) from 7 to 11 December 2015 the annual exhibition "Healthcare" was held. CEO of "MYSTRA-engineering" Nikolay Zinenko carefully bypassed its' avenues and alleys in order to expand the portfolio of medical supplies, and was pleased with what he saw.
If the previous exhibitions were like the New York City, where numerous lively avenues intersect perpendicularly, now, due to the remarkable in its simplicity and effect decision of the sloping rows in hall 2-1, it became more like a metropolis of Southeast Asia - Hong Kong or Singapore, where the geometry of streets is not so angular, and the houses are not placed shoulder to shoulder, but in discord, because everyone has his own Feng shui. But why? Because this year there are fewer participants (we shall not discuss the global economics), whereby the exhibition as a whole looks much more stylish and comfortable. It is more cozy because "the backyard" disappeared - the outermost rows, left to the bored Chinese producers. This year came fewer guests from China, and due to the general scarcity, they have not formed a separate enclave, but were incorporated into the thick of the overall exhibition.
A few years ago, when I compared the show with a similar annual event in Dubai, I was always surprised that in Dubai at the booths of European manufacturers the direct representatives of the manufacturer were seated from which you can hear interesting details about the product from first hands. But in Russia every time on the stand was an employee of the Russian company - the exclusive distributor with the sense of importance of the work accomplished while landing a foreign product. Therefore, Arab Health, and with bizarrely dressed guests from the Middle East, brought to mind the interplanetary party from "Star Wars", while the Expocentre was Russian-Chinese space for people in business suits. Surprisingly, in spite of the statistics of past years and a declared crisis, there were many Europeans this year, and not only in the German Pavilion. As an employee of Portex said: "Can you notice foreigners on our stand?"
What really caught my eye, was a well-designed mid-size stand of a Turkish company, where two Russian girls slipped in their chairs in a half position from boredom. At another stand with interesting Turkish products, negotiators have assured me that the replacement for products of the Chinese and Malay production will occur in the nearest future.
Curious is the further trajectory of Koreans. On a well-decorated stand I was given an elegant catalogue, and because I had to say something, I said a harvested phrase that I am looking for a compromise between expensive and high-quality and low-cost and low-quality products. It turned out that it was a harvested phrase of my opponent on the stand because he had nothing more to say, except to repeat it to me as his own and unique. Then he handed me a card which said "General Manager/Sales" and said that you need to communicate with this man directly, with his superior that throughout our conversation sat in a chair, and did not bother to break away from it.
The Chinese gradually learn Russian, certify their products in Russia, and in big amounts - if it is true - bring to Russia syringes O.E.M.
To make the picture of an international exhibition complete, it is impossible not to mention guests in jackets of an undoubtedly Asian appearance with perfect Russiam, and obviously neither Chinese nor Koreans. Who were they? Of course - businessmen from Kazakhstan. And why so many? All because three weeks later, on the 1st January 2016, Russia and Kazakhstan are to join the Eurasian Economic Union, and to begin a new life and new opportunities, but what this new life is going to be - no one has any idea.
Summarizing the presented producers and sellers of medical plastic consumables (not to mention the gloves, sutures and instruments), because they are our specialty, we can note that at the exhibition were discovered about five existing Russian producers, a couple of producers from Belarus, two official representatives of German companies, one representative of a multinational manufacturer, one manufacturer from South Korea, about a dozen Chinese manufacturers, among which about a half came for the first time with a good proposal in search of an exclusive distributor, and the rest have already received registration certificates for a part of their assortment, and some even have a single Russian representative. Ten Chinese manufacturers are a small percentage of the productive capacity of our powerful neighbor, but to create a branch of the CMEF exhibition in Moscow with endless replications of identical or similar products makes no sense. And, of course, there were trading houses - about a dozen - of which only three or four specialized in supplies, specialization of the remaining was integrated equipment of health care facilities and "yes, you can buy supplies from us, too."
I will note that this is a result of a careful walk through all the rows without the involvement of special statistics from the organizers. Maybe there was someone else, but hidden. Thus, we can say that in the exhibition neither all the foreign participants of the market, nor all domestic manufacturers were present, and why - each case should be dealt with individually, there is no correlation with the size of the company.
Unfortunately, I found virtually nothing new in terms of product design solutions - yes, "in these breathing systems are not the water traps, but sprays!" Wow. Anyway, what I am saying, everyone, yes everyone, even the smallest producer, have «closing positions». Because everyone is involved in electronic trading. When you look at other products, you wonder - how did all this Chinese managed to buy these products from a factory near Moscow to spread it out on their shelves?
Medical equipment - this is a really important and topical product of the exhibition. I am not an expert in this subject, but the presence of small stands of Russian Kulibin with instruments under the brown signs of Ministry of Industry and Trade or loose arouses my sympathy and even optimism. Great. I think everyone saw in the booth of LLC "Pyotr Telegin" a man with a bagde "Pyotr Telegin." There is something of Nizhny Novgorod, Pyotr Tretyakov and Landrin candies in it.
As for the expensive machines that run the show and can afford the booth with a second floor - it is good, if they are really bought and operate in according hospitals.
In summary we can say that in spite of economically determined compactness, the event turned out good. Club format, combined with the fact that many people in the stands moved here through the decades, has well emphasized that the industry exists and is amenable to understanding and analysis. Understanding of this is good and useful for both the captain of one of the ships that fleet, and to Admiral (Minister of the Admiralty) who can man up the fleet wisely or direct properly.
Nikolay Zinenko, 17th of December 2015
MYSTRA-engineering joins the global community of scientists who fight cancer. Our first step on this ground is a dialogue with medical biologists and plant physiologists, who study pharmacological properties of ginseng.
It is well known that in the Far East of Russia the Amur tiger lives and a plant named ginseng grows. Perhaps, it is also known that both the tiger and ginseng are hunted down by the poachers, who sell them to China, where body parts of the first and roots of the second play a great role in local medicine.
We sincerely doubt the benefits of tiger products on man's health, and we are absolutely against poaching. But the ginseng could really be of a great benefit to the humankind.
Now you can find the publications concerning the positive effects of ginseng in any free newspaper. However, information which shows that ginseng is much more than just one more nutritional supplement or herbalife usually is not available to the non-specialists.
So, what are the benefits of the ginseng root? Amongst the different organic substances the root contains, a significant part play glycosides. Plant's glycosides are well-known for a long time, many of them are artificially synthesized, because they are used, for example, in cardiac medications.
Berries of true ginseng Panax ginseng C.A.Mey. Photo by Evgeniy Dunaev.
From different types of ginseng more than 300 types of glycosides were distinguished (ginseng glycosides even have their own name - ginsenosides), properties of which still await their studies. However, it is already known that some of them, from the group of so-called minor ginsenosides, are effectively cause the apoptosis (death) of tumor cells, attacking the receptors on the cell membrane, and also have an indirect anti-tumor effect - via organism immune system stimulation.
In this way, medications with ginseng ginsenosides may become the solution many scientists from all around the world are searching for – the effective medicine against cancer with minimal side effects.
But where can we get such amount of ginseng? The good thing is that there is no need to dig it on the banks of the Amur River, the ginseng is successfully grown in plantations for many years now. But the final product of the plantation is the same dry root, which still needs to be turned into the medication. A more effective and perspective way to get pure ginsenosides turning out to be the cultivation of ginseng cells in industrial bioreactors.
The bioreactor subject seemed very interesting to us, so we've got in touch with our colleagues in Experimental Biological Complex (EBC) of the K.A.Timiryazev Institute of Plant Physiology and Department of Plant Physiology of M.V.Lomonosov Moscow State University.
We've found out that here, in K.A.Timiryazev Institute, scientists learned to cultivate ginseng cells in the bioreactor for a long time, while cells remain a high ability to biosynthesis, which results in a huge volume of substances they produce. A long experience in the investigation of cells taken from medical plants (also from non-related systematic groups), summarized in methods of cell cultivation, which allow the application of technology in industrial scales.
Scientists from EBC have also found out that in sterile cell culture conditions the composition of glycosides does not differ from intact (natural) plants.
We have proposed a joint project to our colleagues - to create a material impregnated with ginsenosides, absorbable in the organism tissue, which forms a local depot for cytotoxic substances that inhibits the proliferation of tumor cells in internal organs. An individual engineering solution will be needed to create a minimally invasive delivery system of this compound to the metastatic tissue. So, a long road lies in front of us, but we'd like to follow it from the first steps till the destination point.
#cancerdrug #cancer #ginseng #ginsenosides #herbalcancerdrug #phytocatheter #phytoprobe
Photos taken from EBC web-page: http://ckp-rf.ru/usu/308100/?sphrase_id=923955