MYSTRA engineering together with the leading Russian bariatric surgeons - professor Vadim Fedenko, MD, PhD (in the head photo) and Vladimir Evdoshenko, MD, PhD starts the development of an innovative product for surgical obesity treatment - adjustable perigastric balloon APGB.
Clinical trials will be held in Central Research Institute of Gastroenterology under the supervision of Head of the Institute professor Igor Khatkov, MD, PhD. Personal commitment in the investigation will take associate professor Rashid Askerkhanov, PhD.
The treatment with APGB bases on the principle of restriction - filling of the inner part of the stomach, and thus reducing its capacity. Due to the possibility to fill the balloon with liquid, the device can be precisely regulated, which helps to increase or reduce the restrictive effect that the system provides. The implantation procedure is easy and safe, because it does not require inner organs opening or intersection, and is performed laparoscopically.
APGB implantation allows to perform precise regulation of the gastric lumen, which makes the result more predictable compared to gastroplication and implantation of intragastric balloon.
After the placement of APGB into the upper part of the stomach, a slot-like lumen is formed, providing a more comfortable nourishment compared to adjustable gastric band.
Important to mention that with APGBexcessive constriction of the band), displacement and migration of the device into the lumen of the stomach, is minimal or is absent.
The operation of APGB implantation is reversible.
In perspective, after the conduction of further clinical trials, the APGB treatment may become a great alternative to the adjustable gastric band and gastroplication.
Visit Dr. Vadim Fedenko personal FB page:
MYSTRA-engineering joins the global community of scientists who fight cancer. Our first step on this ground is a dialogue with medical biologists and plant physiologists, who study pharmacological properties of ginseng.
It is well known that in the Far East of Russia the Amur tiger lives and a plant named ginseng grows. Perhaps, it is also known that both the tiger and ginseng are hunted down by the poachers, who sell them to China, where body parts of the first and roots of the second play a great role in local medicine.
We sincerely doubt the benefits of tiger products on man's health, and we are absolutely against poaching. But the ginseng could really be of a great benefit to the humankind.
Now you can find the publications concerning the positive effects of ginseng in any free newspaper. However, information which shows that ginseng is much more than just one more nutritional supplement or herbalife usually is not available to the non-specialists.
So, what are the benefits of the ginseng root? Amongst the different organic substances the root contains, a significant part play glycosides. Plant's glycosides are well-known for a long time, many of them are artificially synthesized, because they are used, for example, in cardiac medications.
Berries of true ginseng Panax ginseng C.A.Mey. Photo by Evgeniy Dunaev.
From different types of ginseng more than 300 types of glycosides were distinguished (ginseng glycosides even have their own name - ginsenosides), properties of which still await their studies. However, it is already known that some of them, from the group of so-called minor ginsenosides, are effectively cause the apoptosis (death) of tumor cells, attacking the receptors on the cell membrane, and also have an indirect anti-tumor effect - via organism immune system stimulation.
In this way, medications with ginseng ginsenosides may become the solution many scientists from all around the world are searching for – the effective medicine against cancer with minimal side effects.
But where can we get such amount of ginseng? The good thing is that there is no need to dig it on the banks of the Amur River, the ginseng is successfully grown in plantations for many years now. But the final product of the plantation is the same dry root, which still needs to be turned into the medication. A more effective and perspective way to get pure ginsenosides turning out to be the cultivation of ginseng cells in industrial bioreactors.
The bioreactor subject seemed very interesting to us, so we've got in touch with our colleagues in Experimental Biological Complex (EBC) of the K.A.Timiryazev Institute of Plant Physiology and Department of Plant Physiology of M.V.Lomonosov Moscow State University.
We've found out that here, in K.A.Timiryazev Institute, scientists learned to cultivate ginseng cells in the bioreactor for a long time, while cells remain a high ability to biosynthesis, which results in a huge volume of substances they produce. A long experience in the investigation of cells taken from medical plants (also from non-related systematic groups), summarized in methods of cell cultivation, which allow the application of technology in industrial scales.
Scientists from EBC have also found out that in sterile cell culture conditions the composition of glycosides does not differ from intact (natural) plants.
We have proposed a joint project to our colleagues - to create a material impregnated with ginsenosides, absorbable in the organism tissue, which forms a local depot for cytotoxic substances that inhibits the proliferation of tumor cells in internal organs. An individual engineering solution will be needed to create a minimally invasive delivery system of this compound to the metastatic tissue. So, a long road lies in front of us, but we'd like to follow it from the first steps till the destination point.
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Photos taken from EBC web-page: http://ckp-rf.ru/usu/308100/?sphrase_id=923955